Author

Xiaochun Li

The University of Texas Southwestern Medical CenterORCID 0000-0002-0177-0803Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 2 Synthetic Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:cryo-EM· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:protein design· 1

Frequent Co-Authors

Helen H. HobbsiD· 2 shared Rong WangiD· 2 shared Sen Hong· 2 shared A G MurrayiD· 1 shared Adam M. Chazin-GrayiD· 1 shared Anitra C. Wolf· 1 shared Ayesha MisquithiD· 1 shared Brian CoventryiD· 1 shared

Activity by Year

2023-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersCell Biology

Helen H. HobbsORCID

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3 papers

Recent·Most cited

TM6SF2 is a cholesterol-bound homomultimeric ER membrane protein that binds ApoB and is required for bulk lipidation of VLDL

Sen Hong, Jin Wang, Matthew A. Mitsche, Jonathan C. Cohen, Xiaochun Li, Helen H. Hobbs

This study determines the structure of TM6SF2 and shows its role in lipidation of ApoB-containing lipoproteins, with a variant affecting cholesterol binding and function.

bioRxiv · Sep 28, 2026 · PreprintCell Biology

Structure and Function of TM6SF1 Reveal Role in mTORC1 Signaling

Sen Hong, Liangjie Jia, Rong Wang, Nadia Elghobashi‐Meinhardt, Helen H. Hobbs, Xiaochun Li

This study determines the cryo-EM structure of TM6SF1 and shows it regulates mTORC1 signaling through cholesterol-dependent interaction with LAMTOR1, affecting TFEB activation.

Proceedings of the National Academy of Sciences · Sep 14, 2026Peer-reviewedCell Biology

Designed Endocytosis-Triggering Proteins mediate Targeted Degradation and amplify signaling

Buwei Huang, Mohamad H. Abedi, Green Ahn, Brian Coventry, Isaac Sappington, Rong Wang, Thomas Schlichthaerle, Jason Z. Zhang, Yujia Wang, Inna Goreshnik, Ching Wen Chiu, Adam M. Chazin-Gray, Sidney Chan, Stacey Gerben, A G Murray, , David A. Baker

The paper designs EndoTags to trigger endocytosis and degradation of target proteins, enabling tissue-specific targeting and therapeutic applications.

bioRxiv · Aug 19, 2023 · PreprintSynthetic Biology