Sheng-Yong Niu

This study shows ANGPTL7 affects immune cells in the optic nerve head, contributing to neurodegeneration in glaucoma, despite no effect on intraocular pressure.

This paper introduces GEM-1, a generative model that accurately predicts future gene expression experiments, achieving performance comparable to real lab experiments.

The paper develops a multi-omic single-nucleus sequencing method and framework to analyze regulatory genome diversity in human cortical cells and link it to disease risk variants.

The paper compares cellular diversity in the primary motor cortex across human, marmoset, and mouse using single-nucleus transcriptomics and epigenomics, finding conserved cell types and species-specific adaptations.

The paper creates a comprehensive atlas of mouse primary motor cortex cell types using integrated transcriptomic and epigenomic data from over 600,000 samples.

The paper links epigenomic properties of cortical projection neurons to their anatomical and projection patterns using single-nucleus DNA methylation sequencing in mice.

The paper identifies a de novo FOXR1 variant causing microcephaly and brain atrophy by impairing stress response pathways.

rSeqTU is an R package that predicts bacterial transcription units using machine learning, integrating quality control, feature selection, and visualization tools.