Rui Hong

A gene program association study (GPAS) delineates novel patterns of lineage plasticity and aggressiveness in non-small cell lung cancer

The paper introduces GPAS to analyze gene co-expression modules in NSCLC, identifying lineage plasticity and aggressiveness patterns across different cancer subtypes.

Interactive analysis of single-cell data using flexible workflows with SCTK2.0

SCTK2.0 provides an integrated toolkit for scRNA-seq analysis with a graphical interface, enabling non-programmers to perform end-to-end workflows and generate reproducible reports.

Single cell transcriptomic profiling of tauopathy in a novel 3D neuron-astrocyte coculture model

The paper develops a 3D neuron-astrocyte coculture model to study tauopathy, showing it recapitulates pathological features and responds to HSP90 inhibitor treatment.

Comprehensive generation, visualization, and reporting of quality control metrics for single-cell RNA sequencing data

The paper introduces a pipeline for generating, visualizing, and reporting quality control metrics for scRNA-seq data, improving standardization across platforms.

Forkhead box R1-mediated stress response linked to a case of human microcephaly and brain atrophy

The paper identifies a de novo FOXR1 variant causing microcephaly and brain atrophy by impairing stress response pathways.