Yufeng Yang

This study shows linear mRNAs can undergo backward translation in vitro, producing signals comparable to forward translation, and demonstrates the potential of backward translation in synthetic biology.

The paper presents evidence that eukaryotic circular RNAs can be translated in the 3' to 5' direction, producing novel proteins with distinct features, and identifies millions of potential BT proteins across species.

The paper identifies SMARCA4 and ERK-ETS signaling as targets for suppressing aging-related dopaminergic degeneration in Parkinson's disease using gene co-expression analysis and Drosophila models.