Discovery of Semicarbazone and Thiosemicarbazone Analogs as Competitive SARS-CoV-2 Virus Main Protease (Mpro) Inhibitors
Luiza Valença Barreto, Estela Mariana Guimarães Lourenço, Elany Barbosa da Silva, Mariana Ortiz de Godoy, Luan Carvalho Martins, Mariana Laureano de Souza, Renata G. Almeida, Vitor Leonardo Silva Cunha, Magno Carvalho Pires, Stefânia Neiva Lavorato, Thiago Belarmino de Souza, Ana Carolina Oliveira Bretas, Flaviano Melo Ottoni, Eufrânio N. da Silva Júnior, Glaucius Oliva, , Rafaela Salgado Ferreira
This study identifies semicarbazone and thiosemicarbazone analogs as competitive inhibitors of SARS-CoV-2 Mpro through virtual screening and biochemical validation.
bioRxiv · Mar 12, 2026 · PreprintBiochemistry