Haribabu Arthanari

ssDNA hand-off from RPA to Polθ drives microhomology-mediated end-joining

The paper reveals that RPA activates TMEJ by facilitating ssDNA hand-off to Polθ, which initiates microhomology search for DNA repair.

A Phosphorylation Switch Modulates Configurational Codes in the Oncofetal IGF2BP RNA Binding Paralogs

This study shows phosphorylation of IGF2BP1 and IGF2BP3 at a conserved serine acts as a configurational switch, altering their RNA binding domain arrangements and affecting mRNA regulation.

The Role of Conformational Changes in TcmN Aromatase/Cyclase in Polyketide Biosynthesis

This study investigates how conformational changes in TcmN aromatase/cyclase regulate substrate binding and product release during polyketide biosynthesis.

FoxP3 forms a head-to-head dimer in vivo and stabilizes its multimerization on adjacent microsatellites

The paper shows FoxP3 forms head-to-head dimers and stabilizes multimerization on microsatellites in Tregs, revealing a dual DNA-binding mode.

A novel motif in calcimembrin/C16orf74 dictates multimeric dephosphorylation by calcineurin

The paper identifies a novel composite motif in CLMB that enables multimeric dephosphorylation by calcineurin, influencing its membrane localization and signaling.

Structural Insights into the DNA-Binding Mechanism of BCL11A: The Integral Role of ZnF6

This study investigates the DNA-binding mechanism of BCL11A, revealing the role of ZnF6 in repression of {gamma}-globin gene expression and its implications for therapeutic design.

Ergothioneine boosts mitochondrial respiration and exercise performance via direct activation of MPST

This study identifies MPST as the direct target of EGT, showing it enhances mitochondrial respiration and exercise performance in mice.

AI-Enhanced Adaptive Virtual Screening Platform Enabling Exploration of 69 Billion Molecules Discovers Structurally Validated FSP1 Inhibitors

AdaptiveFlow enables large-scale virtual screening of 69 billion molecules to discover validated FSP1 inhibitors, improving efficiency and scalability in drug discovery.

Expanding the HDAC druggable landscape beyond enzymatic activity

This paper identifies a non-enzymatic HDAC inhibitor with anti-tumor and anti-psychedelic effects, showing reduced gene modulation compared to enzymatic inhibitors.