Bispecific antibodies against the hepatitis C virus E1E2 envelope glycoprotein
Laura Radić, Anna Offersgaard, Tereza Kadavá, Ian Zon, Joan Capella-Pujol, Fabian Mulder, Sylvie M. Koekkoek, Vera Spek, Ana Chumbe, Jens Bukh, Marit J. van Gils, Rogier W. Sanders, Victor C. Yin, Albert J. R. Heck, Judith M. Gottwein, , Janke Schinkel
This study generates bispecific antibodies targeting two distinct HCV E1E2 epitopes, showing enhanced neutralization breadth and potency compared to monospecific antibodies.
Proceedings of the National Academy of Sciences · Apr 7, 2025Peer-reviewedMicrobiology