Jens Bukh

The paper proposes a genetic divergence threshold for demarcating orthoflavivirus species, identifying 25 new Euflavivirus and 33 new Fusivirus species.

This paper develops a Norway rat hepacivirus reporter system with a HiBiT tag for high-throughput quantification of neutralising antibodies and antiviral responses.

RMC-113 inhibits PIP4K2C and PIKfyve, reversing SARS-CoV-2-induced autophagic flux impairment and showing antiviral effects.

This study generates bispecific antibodies targeting two distinct HCV E1E2 epitopes, showing enhanced neutralization breadth and potency compared to monospecific antibodies.

The paper redefines the taxonomy of Flaviviridae by integrating protein sequence and structure data, revealing new clades and expanding host range.

The paper determines the structure of HCV E1/E2 envelope proteins in a homodimeric complex using cryo-electron microscopy, revealing details about the dimer interface and antigenic sites relevant to vaccine design.