Author

Doaa A Abo Elwafa

Chiba UniversityORCID 0000-0002-7756-9671Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 2 Organism:human· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Hussein Hassan AlyiD· 2 shared Ikuo ShojiiD· 2 shared Kazuaki ChayamaiD· 2 shared Masanori IsogawaiD· 2 shared Sameh A. GadiD· 2 shared Takaji WakitaiD· 2 shared Daniel MerkiD· 1 shared Kento FukanoiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersMicrobiology

Hussein Hassan AlyORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Identification of molecular determinants governing KIF4 cargo recognition of NTCP and their role in HBV/HDV infection

Sameh A. Gad, Doaa A Abo Elwafa, Masaaki Toyama, Mitsunori Ikeguchi, Ikuo Shoji, Kazuaki Chayama, Masanori Isogawa, Takaji Wakita, Hussein Hassan Aly

The paper identifies a leucine-rich motif in NTCP essential for KIF4-mediated trafficking and HBV/HDV infection, revealing a conserved cargo recognition mechanism shared with integrin β1.

bioRxiv · Feb 26, 2026 · PreprintMicrobiology

RXR agonist S169 inhibits HBV/HDV entry in vitro by disrupting KIF4-dependent NTCP trafficking.

Sameh A. Gad, Doaa A Abo Elwafa, Saied A. Hussein, Kento Fukano, Takanobu Kato, Ikuo Shoji, Kazuaki Chayama, Masamichi Muramatsu, Masanori Isogawa, Takaji Wakita, Daniel Merk, Hussein Hassan Aly

This study identifies S169, an RXR agonist, as an inhibitor of HBV/HDV entry by disrupting KIF4-dependent NTCP trafficking in human hepatocytes.

Antiviral Research · Jun 14, 2025Peer-reviewedMicrobiology