Carsten Sachse

This study uses cryo-electron tomography to show that vesicle fusion contributes to phagophore expansion in yeast during autophagosome biogenesis.

This paper develops ApoE-functionalized fusogenic liposomes to deliver resveratrol to the brain, improving vascular function and cognitive performance in aged mice with reduced drug dosage.

The paper introduces a statistics-based method for local resolution estimation in cryo-EM maps, tomograms, and micrographs to improve quality assessment and reconstruction.

This study determines the cryo-EM structure of p62 and visualizes its filament organization and calcium-rich lipid droplet cargo in cells under stalled autophagy.

The paper shows IM30 binds membranes via a conserved helical hairpin, initiating assembly into higher-order structures that mediate membrane remodeling, revealing a conserved mechanism across ESCRT-III superfamily members.

This study shows how PspA rods thin lipid tubules by inducing membrane curvature through N-terminal helix 0 interactions, overcoming bending energy via molecular mechanisms.

CryoVIA quantifies membrane structures from cryo-EM images by automating segmentation, structure identification, and analysis of membrane properties.

The paper develops a method to measure and control ice thickness in the VitroJet for cryo-EM, improving efficiency in single particle structure determination.

This study presents cryo-EM structures of Vipp1 interacting with bacterial membranes, revealing curvature-dependent structural transitions and membrane remodeling mechanisms.

This paper applies low-dose cryo-EM and 4D-STEM ptychography to achieve sub-nanometer resolution 3D reconstructions of frozen hydrated proteins.

The paper determines cryo-EM structures of PspA rods and shows how structural plasticity is mediated by conformational changes and protomer contacts.

The paper analyzes 61 Chlamydia psittaci genomes to identify genomic features correlated with host tropism and phylogeny.

This study determines the structural basis of p62/SQSTM1 PB1 domain filaments, their role in phase-separated p62 bodies, and their importance in cargo recognition and lysosomal targeting.

The paper determines high-resolution cryo-EM structures of tobacco mosaic virus to elucidate the conformational changes in the disassembly switch mechanism.

This study identifies vault RNA1-1 as a riboregulator of autophagy by interacting with p62, showing that it modulates autophagic flux.