Jacinto López‐Sagaseta

Structure-function profiling identifies determinants of TCR-T cell therapeutic efficacy

The paper identifies structural and functional determinants of TCR efficacy in adoptive T-cell therapy by comparing two GPC3-specific TCRs using structural and functional assays.

Structural presentation of amyloid β by HLA

The paper presents the first experimental structure of an Alzheimer's Aβ peptide bound to an HLA molecule, revealing key interactions and polymorphic binding sites.

Structure of Factor VII Gla domain bound to EPCR

The paper reports the crystal structure of factor VII Gla domain bound to EPCR, revealing structural insights into their binding and competition with PC-EPCR.

Robust TCR production for the structural study of TCR-pMHC complexes

This paper describes a simplified method for producing soluble TCRs in CHO cells with deglycosylation, enabling structural studies of TCR-pMHC complexes with high efficiency.

Unusual traits shape the architecture of the Ig ancestor molecule

The paper identifies novel Ig-domain features in Porifera, suggesting potential primitive adaptive immunity mechanisms.

Severe deviation in protein fold prediction by advanced AI: a case study

This paper reports severe deviations between experimental and AI-predicted protein structures, highlighting limitations in current protein fold prediction methods.