Myeloid deficiency of the intrinsic clock protein Bmal1 accelerates cognitive aging by disrupting microglial synaptic pruning
Chinyere Agbaegbu Iweka, Erica M. Seigneur, Amira Latif‐Hernandez, Sur Herrera Paredes, Mica Cabrera, Eran Blacher, Connie A. Tsai, Frank M. Longo, Luı́s de Lecea, Katrin I. Andreasson
This study shows that Bmal1 deficiency in myeloid cells disrupts microglial synaptic pruning, accelerates cognitive aging, and affects sleep-wake cycles in mice.
Journal of Neuroinflammation · Feb 24, 2023Peer-reviewedNeuroscience