BiophysicsProceedings of the National Academy of SciencesPeer-reviewed
Structural basis for CFTR inhibition by CFTRinh-172
Paul G. Young, Jesper Levring, Karol Fiedorczuk…·Jue Chen
This paper determines the structure of CFTR bound to CFTRinh-172 using cryo-EM, revealing its dual role as a pore blocker and gating modulator.