BiochemistryNature Biomedical EngineeringPeer-reviewed
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Peptide Design through Binding Interface Mimicry
Xiangzhe Kong, Rui Jiao, Haowei Lin…·Jianzhu Ma
PepMimic, an all-atom latent diffusion model guided by a contrastive interface encoder, designs peptides mimicking known binders; 8% of tested peptides across five targets reached 10^-8M KD.