Defining the mechanism of galectin-3-mediated TGF-β1 activation and its role in lung fibrosis.
J Calver, Nimesh R. Parmar, Gemma Harris, Ryan M. Lithgo, Panayiota Stylianou, Fredrik R. Zetterberg, Bibek Gooptu, Alison C. MacKinnon, Stephen B. Carr, Lee Anthony Borthwick, David J. Scott, Iain D. Stewart, Robert J. Slack, Gisli R. Jenkins, Alison E. John
This paper investigates how galectin-3 enhances TGF-β1 activation and signaling in lung fibroblasts, contributing to idiopathic pulmonary fibrosis.
Journal of Biological Chemistry · Apr 17, 2024Peer-reviewedMolecular Biology