Author

David J. Scott

Rutherford Appleton LaboratoryORCID 0000-0002-6726-2078Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 2 Bioinformatics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Gemma HarrisiD· 2 shared Adrianna DąbrowskaiD· 1 shared Alison C. MacKinnoniD· 1 shared Alison E. JohniD· 1 shared Ania WilczynskaiD· 1 shared Anna M. L. PageiD· 1 shared Bibek GooptuiD· 1 shared Danny T. C. HuangiD· 1 shared

Activity by Year

2017-2024 · peak 1/yr

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10 top collaborators · 17 mutual co-author links

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2 shared papersMolecular Biology

Gemma HarrisORCID

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3 papers

Recent·Most cited

Molecular BiologyJournal of Biological ChemistryPeer-reviewedApr 17, 2024

Defining the mechanism of galectin-3-mediated TGF-β1 activation and its role in lung fibrosis.

J Calver, Nimesh R. Parmar, Gemma Harris…·Alison E. John

This paper investigates how galectin-3 enhances TGF-β1 activation and signaling in lung fibroblasts, contributing to idiopathic pulmonary fibrosis.

42 citationstop 2%

humanexperimental assay

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Molecular BiologybioRxivPreprintAug 8, 2022

Purine-rich RNA sequences in the 5'UTR site-specifically regulate eIF4A1-unwinding through eIF4A1-multimerisation to facilitate translation

Tobias Schmidt, Adrianna Dąbrowska, Joseph A. Waldron…·Martin Bushell

The paper identifies AG-rich RNA sequences in 5'UTRs that regulate eIF4A1 multimerisation to enhance translation of oncogenic mRNAs.

1 citation

humanbulk RNA-seq

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BioinformaticsPLoS Computational BiologyPeer-reviewedSep 18, 2017

Reconstructing Promoter Activity From Lux Bioluminescent Reporters

Mudassar Iqbal, Neil Doherty, Anna M. L. Page…·Dov Joseph Stekel

This paper develops a modeling approach to infer gene transcription levels from Lux bioluminescent data, addressing nonlinear dynamics that affect light output.

21 citations

statistical model

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