Author

Lee Anthony Borthwick

Newcastle UniversityORCID 0000-0003-2885-3382Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

A. L. CollinsiD· 1 shared Alison C. MacKinnoniD· 1 shared Alison E. JohniD· 1 shared Andrew J. FilbyiD· 1 shared Andrew John FisheriD· 1 shared Antoine DufouriD· 1 shared Bibek GooptuiD· 1 shared Daniel GehiD· 1 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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1 shared paperCancer Biology

A. L. CollinsORCID

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3 papers

Recent·Most cited

Cell BiologyEuropean Respiratory JournalPeer-reviewedDec 11, 2025

Extracellular Matrix-Induced Genes May Reduce Response to Rapamycin in LAM

Debbie Clements, Roya Babaei‐Jadidi, Jan Johnson…·Simon R. Johnson

This study identifies extracellular matrix genes that reduce rapamycin response in LAM cells and suggests repurposed inhibitors as potential therapies.

6 citationstop 4%

humanproteomics

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Cancer BiologybioRxivPreprintSep 16, 2024

Ex-vivo mouse precision cut tumour slices for modelling hepatocellular carcinoma; A 3Rs solution for at-scale drug screening

A. L. Collins, Keara Kirkness, Erik Ramon‐Gil…·Jack Leslie

This paper develops an ex-vivo model of hepatocellular carcinoma using precision-cut tumour slices to enable efficient and ethical drug screening.

DOI 10.1101/2024.09.16.613213

mouseexperimental assay

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Molecular BiologyJournal of Biological ChemistryPeer-reviewedApr 17, 2024

Defining the mechanism of galectin-3-mediated TGF-β1 activation and its role in lung fibrosis.

J Calver, Nimesh R. Parmar, Gemma Harris…·Alison E. John

This paper investigates how galectin-3 enhances TGF-β1 activation and signaling in lung fibroblasts, contributing to idiopathic pulmonary fibrosis.

42 citationstop 2%

humanexperimental assay

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