Short-chain di-carboxylates as positive allosteric modulators of the pH-dependent pentameric ligand-gated ion channel GLIC: requirement of an intact vestibular pocket
Catherine Van Renterghem, Ákos Nemecz, Sandrine Delarue‐Cochin, Delphine Joseph, Pierre‐Jean Corringer
The paper shows short-chain di-carboxylates modulate GLIC activity, with fumarate being the most potent, and reports a Cs+/Na+ permeability ratio for GLIC.
bioRxiv · Mar 3, 2023 · PreprintNeuroscience