Pierre‐Jean Corringer

The paper introduces an optonanobody that reversibly photoactivates native alpha7 nicotinic receptors without genetic modification, demonstrating its effectiveness in Xenopus oocytes and hippocampal slices.

This study shows that the interpeduncular nucleus (IPN) regulates nicotine reward by modulating VTA neuron activity through β4-containing nAChRs.

This study investigates two Kir2.1 mutants linked to Andersen-Tawil syndrome, showing they impair channel function through distinct mechanisms, with C154Y causing dominant-negative effects.

This study uses voltage-clamp fluorometry to map conformational changes in the 5-HT3 serotonin-gated channel, linking them to electrophysiological states and agonist effects.

The paper solves cryo-EM structures of human α7 nicotinic receptor nanobody complexes, revealing E3's mechanism of inducing active or desensitized conformations through a N-linked sugar moiety.

This paper describes the generation of nanobodies that act as silent and positive allosteric modulators of the α7 nicotinic acetylcholine receptor, with distinct functional properties.

The paper identifies a mutation in the pre-β5 strand of GLIC that changes crotonate from a negative to positive modulator, suggesting its role in coupling ligand binding to pore gating.

The paper shows short-chain di-carboxylates modulate GLIC activity, with fumarate being the most potent, and reports a Cs+/Na+ permeability ratio for GLIC.