Ákos Nemecz

Generation of nanobodies acting as silent and positive allosteric modulators of the α7 nicotinic acetylcholine receptor

This paper describes the generation of nanobodies that act as silent and positive allosteric modulators of the α7 nicotinic acetylcholine receptor, with distinct functional properties.

Short-chain mono-carboxylates as negative modulators of allosteric transitions in GLIC, and impact of a pre-β5 strand (Loop {Omega}) double mutation on crotonate, not butyrate effect.

The paper identifies a mutation in the pre-β5 strand of GLIC that changes crotonate from a negative to positive modulator, suggesting its role in coupling ligand binding to pore gating.

Short-chain di-carboxylates as positive allosteric modulators of the pH-dependent pentameric ligand-gated ion channel GLIC: requirement of an intact vestibular pocket

The paper shows short-chain di-carboxylates modulate GLIC activity, with fumarate being the most potent, and reports a Cs+/Na+ permeability ratio for GLIC.