NeurosciencebioRxivPreprint
Short-chain mono-carboxylates as negative modulators of allosteric transitions in GLIC, and impact of a pre-β5 strand (Loop {Omega}) double mutation on crotonate, not butyrate effect.
Catherine Van Renterghem, Ákos Nemecz, Karima Medjebeur, Pierre‐Jean Corringer
The paper identifies a mutation in the pre-β5 strand of GLIC that changes crotonate from a negative to positive modulator, suggesting its role in coupling ligand binding to pore gating.