Surabhi Chowdhary

Chaperone condensates buffer the heat shock response against pleiotropic inputs

The paper shows that chaperone condensates specifically buffer the heat shock response, setting activation thresholds and ensuring specificity to heat shock in budding yeast.

Emergent 3D genome reorganization from the stepwise assembly of transcriptional condensates

The paper shows transcriptional condensates form stepwise in yeast to enable graded and 3D gene control during heat shock response.

Inducible transcriptional condensates drive 3D genome reorganization in the heat shock response

This study identifies inducible transcriptional condensates in yeast heat shock response and shows they drive 3D genome reorganization through Hsf1-mediated gene coalescence.

Heat Shock Factor 1 Drives Intergenic Association of Its Target Gene Loci Upon Heat Shock

This study shows that Hsf1 drives intergenic interactions of HSP gene loci in yeast during heat shock, forming subnuclear foci that dissolve with transcriptional attenuation.