David S. Gross

The paper identifies Mediator Tail subunits' roles in coordinating transcriptional condensates, genome organization, and gene activation during heat shock in yeast.

This study identifies Apj1 and Ydj1 as J-domain proteins that regulate Hsf1 in distinct phases of the heat shock response in yeast.

This study shows that Nup2 and Mlp1 drive 3D genome restructuring of HSR genes after transcriptional activation during heat shock in budding yeast.

This paper shows that Hsf1 forms condensates and restructures the yeast genome before activating HSR genes in response to ethanol stress, with different kinetics compared to thermal stress.

The paper shows that Pol II CTD phosphorylation, specifically Ser2 phosphorylation, is critical for activating a heterochromatic gene in yeast, suggesting an alternative mechanism to histone modifications.

This study identifies inducible transcriptional condensates in yeast heat shock response and shows they drive 3D genome reorganization through Hsf1-mediated gene coalescence.

This study shows that Hsf1 drives intergenic interactions of HSP gene loci in yeast during heat shock, forming subnuclear foci that dissolve with transcriptional attenuation.

The paper quantifies Hsf1 binding and transcription in yeast under basal and heat shock conditions, revealing a continuum of Hsf1 occupancy and activity across the genome.