ANP32E drives vulnerability to ATR inhibitors by inducing R-loops-dependent Transcription Replication Conflicts in Triple Negative Breast Cancer
Sara Lago, Vittoria Poli, Lisa Fol, Mattia Botteon, Federica Busi, Alice Turdo, Miriam Gaggianesi, Yari Ciani, Giacomo D’Amato, Luca Fagnocchi, Alessandra Fasciani, Francesca Demichelis, Matilde Todaro, Alessio Zippo
The paper identifies ANP32E as a driver of vulnerability to ATR inhibitors in triple-negative breast cancer by promoting R-loop-dependent transcription replication conflicts and genomic instability.
Nature Communications · May 17, 2025Peer-reviewedCancer Biology