Luca Fagnocchi

Chronic obesity does not alter cancer incidence in Tp53R270H/+ mice

This study shows chronic high-fat diet-induced obesity does not increase cancer incidence in Trp53R270H/+ mice, despite significant obesity and long-term adiposity differences.

Midbrain Tet1 dosage defines inter-individual binge-eating susceptibility

This study shows that Tet1 dosage in midbrain neurons determines binge-eating susceptibility in mice and links Tet1 methylation to human binge-eating behavior.

BifurcatoR: A Framework for Revealing Clinically Actionable Signal in Variance Masquerading as Noise

BifurcatoR identifies clinically relevant subgroups by analyzing variance patterns in biological data, revealing hidden structures in AML and obesity.

ANP32E drives vulnerability to ATR inhibitors by inducing R-loops-dependent Transcription Replication Conflicts in Triple Negative Breast Cancer

The paper identifies ANP32E as a driver of vulnerability to ATR inhibitors in triple-negative breast cancer by promoting R-loop-dependent transcription replication conflicts and genomic instability.

Metastatic cell plasticity is maintained by SOX9 function during mitosis in breast cancer

The paper shows that SOX9 maintains metastatic cell plasticity during mitosis by priming chromatin accessibility for dormancy-related transcriptional programs in breast cancer.