Charles R. Goodlett

This study examines sex-specific developmental effects of neonatal Dyrk1a reduction in Ts65Dn Down syndrome mice, finding partial improvements in some phenotypes but not all.

The paper compares skeletal phenotypes between two Down syndrome mouse models, Ts65Dn and Ts66Yah, using a novel PCA-based method to assess the impact of non-Hsa21 trisomic genes on bone structure and function.

This paper shows that deleting the mbk-1 gene in C. elegans impairs locomotion but not chemosensory function or learning, and humanized replacement restores normal movement.