NeuroscienceScience AdvancesPeer-reviewed
Lysosomal dysfunction in Down Syndrome and Alzheimer mouse models is caused by selective v-ATPase inhibition by Tyr682 phosphorylated APP βCTF
Eunju Im, Ying Jiang, Philip H. Stavrides…·Ralph A. Nixon
This study identifies that phosphorylated APP βCTF inhibits v-ATPase in Down Syndrome and Alzheimer's models, leading to lysosomal dysfunction.