NeurosciencebioRxivPreprint
A novel antidepressant acting via allosteric inhibition of GluN2D-incorporated NMDA receptors at GABAergic interneurons
Jilin Zhang, Jinjin Duan, Luyu Ye…·Fei Guo
The paper identifies YY-23, a compound that inhibits GluN2D-containing NMDARs in GABAergic interneurons, showing antidepressant effects in animal models.
DOI 10.1101/2022.11.06.514872