Fei Guo

Hippocampal Glucuronyl C5-epimerase promotes stress resilience by directly engaging PI3K through a non-enzymatic mechanism

This study identifies Glce as a non-enzymatic regulator of hippocampal dendritic integrity and stress resilience through direct activation of PI3K, revealing a novel mechanism in depression pathophysiology.

Distinct structure and gating mechanism in diverse NMDA receptors with GluN2C and GluN2D subunits

The paper reports cryo-EM structures of NMDA receptors with GluN2C and GluN2D subunits, revealing structural and functional differences in their gating mechanisms.

A novel antidepressant acting via allosteric inhibition of GluN2D-incorporated NMDA receptors at GABAergic interneurons

The paper identifies YY-23, a compound that inhibits GluN2D-containing NMDARs in GABAergic interneurons, showing antidepressant effects in animal models.