Hu Zhou

AM-DMF-SCP-pro enables rapid, low-background single-cell proteome profiling in complex samples by streamlining sample preparation and reducing background interference.

This study identifies statins as effective in targeting chemoresistant pancreatic cancer by inhibiting cholesterol metabolism and protein glycosylation, showing clinical benefit in a phase 2 trial.

This paper develops a mass spectrometry-based method to decode glycoproteins by integrating deglycosylation and glycosylation site characterization, enabling accurate sequencing of complex glycosylated proteins.

This paper introduces a new proximity labeling method using photoactivated SOPP3 and APEX2 to enable high spatio-temporal resolution in live cells without exogenous H2O2 or cytotoxicity.

The paper identifies YY-23, a compound that inhibits GluN2D-containing NMDARs in GABAergic interneurons, showing antidepressant effects in animal models.

This paper standardizes a proteotype analysis workflow across multiple international sites to enable distributed, reproducible proteomic data generation for precision medicine.

This study quantifies genomic, proteomic, and phenotypic variability in HeLa cells across laboratories and passages, revealing implications for research reproducibility.