Meningeal inflammation in multiple sclerosis induces phenotypic changes in cortical microglia that differentially associate with neurodegeneration
Lynn van Olst, Carla Rodriguez-Mogeda, Carmen Picón, Svenja Kiljan, Rachel James, Alwin Kamermans, Susanne M. A. van der Pol, Lydian Knoop, Iliana Michailidou, Evelien H.G.M. Drost, Marc Franssen, Geert J. Schenk, Jeroen J.G. Geurts, Sandra Amor, Nicholas D. Mazarakis, , Maarten E. Witte
The paper identifies two distinct microglial phenotypes in progressive MS patients and a rat model, showing they differentially associate with neurodegeneration.
Acta Neuropathologica · Mar 29, 2021Peer-reviewedNeuroscience