Sandra Amor

The paper uses single nuclei RNAseq to identify distinct glial gene expression patterns in MS patients, revealing subgroup-specific pathological processes and suggesting precision medicine approaches.

The paper shows TSPO expression increases in activated microglia in rodent models but not in human neurodegenerative diseases, indicating species-specific differences in TSPO function.

The paper identifies early transcriptomic changes in brain macrophages in MS tissue, linking them to lesion development and suggesting potential therapeutic targets.

The paper identifies two distinct microglial phenotypes in progressive MS patients and a rat model, showing they differentially associate with neurodegeneration.