Geert J. Schenk

The paper investigates misfolded proteolipid protein (PLP1) and amyloid deposition in multiple sclerosis brains, finding PLP1 resistance to denaturation and its association with pathological features.

This study uses human post-mortem brain slice cultures to investigate focal and subtle myelin damage in multiple sclerosis, showing the model's utility for studying human myelin pathology.

This study uses third harmonic generation microscopy to image myelin in live human brain tissue, revealing its utility in detecting subtle myelin changes in neurological conditions.

The paper investigates complement system involvement in synapse loss in MS hippocampus, finding C1q deposits linked to inhibitory synapse loss and impaired memory.

The paper identifies two distinct microglial phenotypes in progressive MS patients and a rat model, showing they differentially associate with neurodegeneration.

This study shows that ER stress in DRG neurons contributes to pain in MS and that ER stress modulators can reduce pain hypersensitivity in an EAE model.