Helga E. de Vries

This study integrates postmortem PD microglia, iPSC-derived microglial progenitors, and iPSC-derived microglia into midbrain organoids, showing that postmortem microglia have higher infiltration capacity and better markers of maturity.

This study presents a one-step protocol to differentiate hiPSCs into functional astrocytes, enabling co-culture with neurons to support network development.

This paper develops a human iPSC-based model of the blood-brain barrier by co-culturing endothelial cells with pericytes and activating Wnt/β-catenin signaling, resulting in cells with BBB-like properties and gene expression patterns.

The paper identifies two distinct microglial phenotypes in progressive MS patients and a rat model, showing they differentially associate with neurodegeneration.