Rachel James

Computationally Designed RNA Aptamers Enable Selective Detection of FUS Pathology in ALS

This study uses RNA aptamers to detect pathological FUS in ALS, showing improved specificity and sensitivity compared to antibodies.

Patient-specific responses to SMN2 splice-modifying treatments in spinal muscular atrophy fibroblasts

The paper analyzes responses to SMN2 splice-modifying treatments in SMA fibroblasts, finding variability in treatment efficacy based on patient-specific factors.

TNF-mediated neuroinflammation is linked to neuronal necroptosis in Alzheimer's disease hippocampus

This study shows that TNF-mediated necroptosis, not apoptosis, contributes to neuronal loss in Alzheimer's disease and is a potential therapeutic target.

Meningeal inflammation in multiple sclerosis induces phenotypic changes in cortical microglia that differentially associate with neurodegeneration

The paper identifies two distinct microglial phenotypes in progressive MS patients and a rat model, showing they differentially associate with neurodegeneration.

Neuroinflammation in the normal appearing white matter of multiple sclerosis brain causes abnormalities at the node of Ranvier

The paper shows that neuroinflammation in MS brains causes structural changes at the node of Ranvier, leading to axonal conduction failure.