Nicholas D. Mazarakis

Astroglial Dysfunction in Models of CDKL5 Deficiency Disorder

This study generates novel human models of CDKL5 Deficiency Disorder and identifies astrocytic dysfunction in these models.

Focal astrocyte Kir4.1 loss drives seizures, spreading depolarizations and postictal impairments

This study shows that focal loss of astrocytic Kir4.1 in the adult hippocampus causes seizures, spreading depolarizations, and postictal impairments.

Lymphotoxin-alpha expression in the meninges causes lymphoid tissue formation and neurodegeneration

This study shows that chronic lymphotoxin-alpha overexpression in rat meninges leads to lymphoid-like structures and neurodegeneration resembling multiple sclerosis.

Meningeal inflammation in multiple sclerosis induces phenotypic changes in cortical microglia that differentially associate with neurodegeneration

The paper identifies two distinct microglial phenotypes in progressive MS patients and a rat model, showing they differentially associate with neurodegeneration.

Neuroinflammation in the normal appearing white matter of multiple sclerosis brain causes abnormalities at the node of Ranvier

The paper shows that neuroinflammation in MS brains causes structural changes at the node of Ranvier, leading to axonal conduction failure.

Cyclin-dependent-like kinase 5 is required for pain signalling in both human neurons and mouse models

This study identifies Cdkl5's role in pain signaling through its interaction with CaMKII in both human neurons and mouse models of Cdkl5 deficiency disorder.