NeuroscienceNature CommunicationsPeer-reviewed
Phosphatidic acid is an endogenous negative regulator of PIEZO2 channels and mechanical sensitivity
Matthew Gabrielle, Yevgen K. Yudin, Yujue Wang…·Tibor Rohács
The paper identifies phosphatidic acid and its analogues as lipid regulators that selectively inhibit PIEZO2 channels, revealing the PLD pathway's role in modulating PIEZO2 activity and mechanical sensitivity.
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