John Smith Del Rosario

This paper constructs a human dorsal root ganglion reference atlas, identifying 22 neuronal subtypes and 10 non-neuronal cell types, and reveals functional differences between human and mouse DRG neurons.

This study creates a single-nucleus multi-omic atlas of human dorsal root ganglia, identifying novel regulatory mechanisms and therapeutic targets for pain.

This study links electrical properties to transcriptional identities in human sensory neurons, identifying associations between pain history and specific electrophysiological subtypes.

The paper investigates FGFR3 expression in human peripheral nervous system tissues and finds no detectable mRNA or protein expression in nerve or dorsal root ganglia, suggesting FGFR3 autoantibodies may not directly cause neuropathy.

The paper builds harmonized cross-species cell atlases of DRG and TG, identifies 29 cell types across 6 species, and shows transcriptomic similarities and differences in sensory neurons.

This study investigates the role of L-type and TRPC3 calcium channels in pericyte calcium signaling and hemodynamics across different cerebrovascular regions in vivo.

This study characterizes bradykinin receptor expression and function in human dorsal root ganglia neurons, finding conserved acute hyperexcitability and age/pain history-related B1 receptor expression.

This study shows that sustained depolarization reduces excitability in mouse and human sensory neurons through decreased voltage-gated sodium currents, suggesting homeostatic plasticity may be altered in chronic pain.

The paper shows TACAN inhibits Piezo2 channel activity in DRG neurons without affecting Piezo1 or TREK1 currents.

This study shows that Gi-coupled receptor activation enhances Piezo2 currents through Gβγ signaling in DRG neurons and heterologous systems.