Author

Boel Brynedal

Karolinska InstitutetORCID 0000-0002-7872-2981Unclaimed ORCID profile · follow to get notified of new preprints

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Boel Brynedal1 paper

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:statistical model· 2 Research Focus:benchmarking· 1 Research Focus:gene regulatory network inference· 1 Assay:GWAS summary statistics· 1 Organism:human· 1 Approach:simulation· 1

Frequent Co-Authors

Daniel RamsköldiD· 2 shared Lina-Marcela Díaz-GalloiD· 2 shared Helga WesterlindiD· 1 shared Karine CheminiD· 1 shared Klementy ShchetynskyiD· 1 shared Lars KlareskogiD· 1 shared Lars S. AlfredssoniD· 1 shared Lasse FolkerseniD· 1 shared

Activity by Year

2018-2021 · peak 1/yr

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10 top collaborators · 33 mutual co-author links

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2 shared papersGenetics

Daniel RamsköldORCID

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2 papers

Recent·Most cited

GeneticsPLoS ONEPeer-reviewedApr 26, 2021

Understanding interactions between risk factors, and assessing the utility of the additive and multiplicative models through simulations

Lina-Marcela Díaz-Gallo, Boel Brynedal, Helga Westerlind…·Daniel Ramsköld

The paper simulates interactions between risk factors to assess additive and multiplicative models, finding that synergistic factors lead to multiplicative risks and thresholds create intermediate effects.

28 citations

statistical modelsimulation

GeneticsAnnals of the Rheumatic DiseasesPeer-reviewedJul 2, 2018

The association between the HLA-DRB1 shared epitope alleles and the risk of rheumatoid arthritis is influenced by massive gene-gene interactions.

Lina-Marcela Díaz-Gallo, Daniel Ramsköld, Klementy Shchetynsky…·Leonid Padyukov

The paper shows that HLA-DRB1 shared epitope alleles' risk for ACPA-positive RA is significantly influenced by interactions with non-HLA SNPs.

25 citations

humanGWAS summary statistics