Lars S. Alfredsson

This study analyzes ancient DNA from three European sites to assess the genomic impact of the second plague pandemic, finding no strong positive selection but evidence of reduced long-range immigration post-pandemic.

This study conducts a trans-ancestry GWAS of rheumatoid arthritis, identifying 124 loci, 34 novel, and shows improved polygenic risk score performance across populations.

This study examines the genetic structure of the Norwegian population, identifying two distinct genetic regions and highlighting the impact of geography on migration patterns and ancestry.

The paper benchmarks disease module identification methods using GWAS and validates a multi-omic module strongly associated with multiple sclerosis risk factors.

This study identifies cell types associated with brain complex traits using GWAS and single-cell transcriptomics, revealing novel roles for oligodendrocytes in Parkinson's disease.

The paper estimates genetic correlations between eating disorder and substance-use-related phenotypes using GWAS data, finding both positive and negative associations.

The paper identifies low-frequency coding variants contributing to multiple sclerosis risk using a large case-control study.

The paper shows that HLA-DRB1 shared epitope alleles' risk for ACPA-positive RA is significantly influenced by interactions with non-HLA SNPs.