Tissue resident memory CD4+ T cells are sustained by site-specific levels of self-renewal and continuous replacement
Jodie S. Chandler, M. Elise Bullock, Arpit Chandan Swain, Cayman Williams, Christiaan Hendrik van Dorp, Benedict P. Seddon, Andrew J. Yates
The paper quantifies self-renewal and replacement rates of CD4+ TRM in skin and gut LP using fate mapping and models, finding site-specific differences in residency and turnover.
eLife · Jun 25, 2025Peer-reviewedImmunology