Author

Benedict P. Seddon

University College LondonORCID 0000-0003-4352-3373Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:mouse· 5 Research Focus:development & morphogenesis· 4 Research Focus:cell type annotation· 3 Research Focus:cell signaling & trafficking· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Andrew J. YatesiD· 3 shared Thea V. HoganiD· 3 shared Cayman WilliamsiD· 2 shared Farjana IslamiD· 2 shared Inês Boal‐Carvalho· 2 shared Sanket RaneiD· 2 shared Apoorva Singh· 1 shared Arpit Chandan SwainiD· 1 shared

Activity by Year

2025-2026 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersImmunology

Andrew J. YatesORCID

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Quorum sensing underlies the establishment and maintenance of marginal zone B cells

Apoorva Singh, Melissa Verheijen, Thea V. Hogan, Andrew J. Yates, Benedict P. Seddon, Sanket Rane

This study identifies quorum sensing mechanisms that regulate the establishment and maintenance of marginal zone B cells in mice through developmental and homeostatic processes.

bioRxiv · Jul 17, 2026 · PreprintImmunology

Tissue resident memory CD4+ T cells are sustained by site-specific levels of self-renewal and continuous replacement

Jodie S. Chandler, M. Elise Bullock, Arpit Chandan Swain, Cayman Williams, Christiaan Hendrik van Dorp, Benedict P. Seddon, Andrew J. Yates

The paper quantifies self-renewal and replacement rates of CD4+ TRM in skin and gut LP using fate mapping and models, finding site-specific differences in residency and turnover.

eLife · Jun 25, 2025Peer-reviewedImmunology

A linear ontogeny accounts for the development of naive, memory and tumour-infiltrating regulatory T cells in mice

Sanmoy Pathak, Thea V. Hogan, Sanket Rane, Yundi Huang, Claire F. Pearson, Charles Sinclair, Simon T. Barry, Larissa S. Carnevalli, Andrew J. Yates, Benedict P. Seddon

This study maps the ontogeny of Treg subsets in mice, showing naive and effector/memory Treg are continuously replenished by de novo generation, with naive Treg being the main precursor of EM Treg in adults.

Science Immunology · Jun 20, 2025Peer-reviewedImmunology

Contrasting roles for IKK regulated inflammatory signalling pathways for development and maintenance of type 1 and adaptive γδ T cells

Farjana Islam, Cayman Williams, Thea V. Hogan, Louise V. Webb, Inês Boal‐Carvalho, Benedict P. Seddon

This study investigates the role of IKK-regulated inflammatory pathways in the development and survival of type 1 and adaptive γδ T cells, revealing distinct requirements compared to β T cells.

bioRxiv · May 8, 2025Immunology

Evidence for a RIPK1-independent survival mechanism for CASPASE-8 in αβ T cells

Farjana Islam, Scott Layzell, Inês Boal‐Carvalho, Benedict P. Seddon

This study identifies a CASPASE8-dependent survival mechanism in CD8 T cells independent of RIPK1-mediated necroptosis suppression.

Discovery Immunology · Jan 1, 2025Peer-reviewedImmunology