Author

Brooke A. DeRosa

University of MiamiORCID 0000-0002-7878-9799Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genomics· 2 Cell Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Assay:bulk RNA-seq· 3 Research Focus:differential expression· 3 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Approach:statistical model· 2 Assay:ATAC-seq· 1

Frequent Co-Authors

Derek Michael DykxhoorniD· 3 shared Aura María RamíreziD· 2 shared Farid RajabliiD· 2 shared Goldie S. ByrdiD· 2 shared Jeffery M. VanceiD· 2 shared Juan I. YoungiD· 2 shared Larry Deon Adams· 2 shared Margaret Ann Pericak‐VanceiD· 2 shared

Activity by Year

2019-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersCell Biology

Derek Michael DykxhoornORCID

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Author profile →

4 papers

Recent·Most cited

Cell BiologybioRxivPreprintOct 22, 2026

LMNA Haploinsufficiency in Human iPSC-Derived Cardiac Organoids Reveals Early Fibrotic Signaling as a Therapeutically Targetable Process

A. Zuniga, Raúl A Dulce, Karina Dutra Asensi…·Stefan Kurtenbach

This study uses cardiac organoids derived from patient iPSCs to show that LMNA haploinsufficiency causes early fibrotic signaling, which can be targeted by antifibrotic drugs.

DOI 10.64898/2026.03.25.714182

humanbulk RNA-seq

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NeuroscienceAlzheimer s & DementiaPeer-reviewedMar 30, 2026

Disrupted Lipid Homeostasis as a Pathogenic Mechanism in ABCA7-Associated Alzheimers Disease Risk

Younji Nam, Brooke A. DeRosa, Aura María Ramírez…·Margaret Ann Pericak‐Vance

This paper investigates the impact of an ancestry-specific ABCA7 deletion on lipid homeostasis in Alzheimer's disease, showing disrupted lipid regulation in neurons.

DOI 10.1002/alz.71312

humanbulk RNA-seq

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GenomicsbioRxivPreprintAug 27, 2024

Gene expression and chromatin accessibility comparison in iPSC-derived microglia in African, European, and Amerindian genomes in Alzheimer's patients and controls.

Sofia Moura, Luciana Bertholim Nasciben, Aura María Ramírez…·Jeffery M. Vance

DOI 10.1101/2024.08.27.609943

humanATAC-seq

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GenomicsbioRxivPreprintMay 15, 2019

Improved single-cell ATAC-seq reveals chromatin dynamics of in vitro corticogenesis

Ryan M. Mulqueen, Brooke A. DeRosa, Casey A. Thornton…·Andrew Adey

The paper introduces an improved single-cell ATAC-seq method, scip-ATAC-seq, which enhances chromatin dynamics analysis in human corticogenesis organoids.

13 citations

humanscATAC-seq

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