Raúl A Dulce

This study uses cardiac organoids derived from patient iPSCs to show that LMNA haploinsufficiency causes early fibrotic signaling, which can be targeted by antifibrotic drugs.

This study identifies the HIF-1 pathway as mediating the cardioprotective effects of GHRH-agonists in a murine model of cardiometabolic HFpEF.

This study identifies ER stress and nitroso-redox imbalance as key drivers of NEPC progression and shows that NO supplementation reduces tumor burden and metastasis in mice.