Hao Chi

TAIMS improves cross-link and low-abundance peptide identification by enhancing MS2 quality and sensitivity in proteomics.

The paper introduces pLink-UBL, a software tool for identifying UBL modification sites on proteins and small-molecule substrates, and discovers spermidine as a small-molecule substrate of SUMO in fission yeast and mammals.

DiNovo improves de novo peptide sequencing by using mirror proteases and deep learning, achieving higher coverage and confidence than single-protease methods.

pChem assesses chemoproteomic probe performance by evaluating modification-homogeneity, profiling efficiency, and residue selectivity using isotopically coded probe-derived modifications.

Open-pFind improves peptide identification in shotgun proteomics by handling complex modifications and increasing identification rates and speed.