Author

Guang-Can Shao

National Institute of Biological Sciences, Beijing

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Research Focus:protein folding & dynamics· 2 Assay:proteomics· 2 Approach:deep learning· 1 Organism:fungi (other)· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Li-Lin DuiD· 2 shared Meng‐Qiu DongiD· 2 shared Ao-Cheng Hou· 1 shared Chenxi ZouiD· 1 shared Fang SuoiD· 1 shared Hao ChiiD· 1 shared Jianhua SuiiD· 1 shared Jing WangiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersCell Biology

Li-Lin DuORCID

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3 papers

Recent·Most cited

BiochemistrybioRxivPreprintSep 3, 2026

Enhancing the Identification of NHS Ester-Mediated Lysine-Cysteine Cross-Linking via Reduced Trypsin Digestion Time

Xin-Feng Yang, Ao-Cheng Hou, Qian Sun…·Guang-Can Shao

This study shows NHS ester cross-linkers can reliably form lysine-cysteine cross-links in XL-MS, improving protein structure analysis by capturing both K-K and K-C distance constraints.

DOI 10.64898/2026.09.02.748724

proteomicsexperimental assay

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Cell BiologyNature CommunicationsPeer-reviewedMar 31, 2026

Nucleophagy is promoted by two autophagy receptors and inhibited by chromatin-nuclear envelope tethering in fission yeast

Zhu-Hui Ma, Zhao-Qian Pan, Zhaodi Jiang…·Li-Lin Du

This study identifies Npr1 as a nucleophagy receptor in fission yeast and shows that chromatin-nuclear envelope tethering inhibits nucleophagy.

3 citationstop 1%

fungi (other)experimental assay

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BiochemistryMolecular & Cellular ProteomicsPeer-reviewedApr 18, 2025

Global analysis of protein and small-molecule substrates of ubiquitin-like proteins (UBLs)

Guang-Can Shao, Zhen-Lin Chen, Shan Lu…·Meng‐Qiu Dong

The paper introduces pLink-UBL, a software tool for identifying UBL modification sites on proteins and small-molecule substrates, and discovers spermidine as a small-molecule substrate of SUMO in fission yeast and mammals.

1 citation

humanmouse

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