Author

Mathilde R. Rivaud

Amsterdam UMC Location University of AmsterdamORCID 0000-0002-0680-3483Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Developmental Biology· 1 Molecular Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Vincent M. ChristoffelsiD· 3 shared Alexandra E. Giovou· 2 shared Arie O. VerkerkiD· 2 shared Arnie BoenderiD· 2 shared Gerard J.J. BoinkiD· 2 shared Karel van DuijvenbodeniD· 2 shared Mischa KlerkiD· 2 shared Anja EhrhardtiD· 1 shared

Activity by Year

2023-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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3 shared papersPhysiology

Vincent M. ChristoffelsORCID

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3 papers

Recent·Most cited

Adeno-associated virus (AAV)-TBX18 does not generate biological pacemaker activity, unlike AAV-Hcn2

Jianan Wang, Mathilde R. Rivaud, Mischa Klerk, Arnie Boender, Ruud N. Visser, Rinske Sparrius, Hee Young Lee, Karel van Duijvenboden, Huiling Zhou, Yuting Yang, Emiel Kramer, Kyung Ho Park, Larry C. Park, Silke Schrödel, Christian Thirion, , Gerard J.J. Boink

This study compares AAV-TBX18 and AAV-Hcn2 in generating biological pacemaker activity, finding TBX18 ineffective while Hcn2 induces robust ectopic pacing.

Journal of Clinical Investigation · Jun 11, 2026Peer-reviewedPhysiology

TBX5 dosage governs ventricular cardiomyocyte maturation, specialization and dedifferentiation in vivo

Alexandra E. Giovou, Otto J. Mulleners, Rocco Caliandro, Vincent A J Warnaar, Arnie Boender, Mischa Klerk, Mathilde R. Rivaud, Diederik W.D. Kuster, Mauro Giacca, Bjarke Krogstrup Jensen, Gerard J.J. Boink, Monika M Gladka, Vincent M. Christoffels

This study shows how varying TBX5 levels in cardiomyocytes affects their maturation, specialization, and dedifferentiation, revealing a non-linear relationship with cardiac function.

bioRxiv · Apr 15, 2026 · PreprintDevelopmental Biology

An atrial fibrillation-associated regulatory region modulates cardiac Tbx5 levels and arrhythmia susceptibility

Fernanda M. Bosada, Karel van Duijvenboden, Alexandra E. Giovou, Mathilde R. Rivaud, Jae‐Sun Uhm, Arie O. Verkerk, Bastiaan J. Boukens, Vincent M. Christoffels

eLife · Jan 30, 2023Peer-reviewedMolecular Biology