Pancreatic cancer-intrinsic HuR regulates the pro-tumorigenic properties of extracellular vesicles
Jennifer M. Finan, Yifei Guo, Alexandra Q. Bartlett, Matthew Reyer, Kevin Hawthorne, Margaret E. Haerr, Hen Halamish, Olayinka Lamikanra, Valerie S. Calvert, Canping Chen, Zheng Xia, Emanuel F. Petricoin, Rosalie C. Sears, Katelyn T. Byrne, Jonathan Robert Brody
This study shows that HuR in pancreatic cancer cells enhances angiogenesis by modulating extracellular vesicle signaling to endothelial cells, increasing their migratory and tube-forming abilities while reducing ICAM-1 expression.
bioRxiv · Feb 8, 2025 · PreprintCancer Biology