Kei Takahashi

The paper develops a new calcium indicator, HiCaRI, based on the photostable mStayGold protein, showing improved brightness and photostability compared to existing GFP-based indicators.

The paper develops a photostable pH biosensor called serapH using mStayGold as a scaffold and introduces a screening method for pH-sensitive FPs in bacterial colonies.

The paper introduces OCaMP, an orange fluorescent calcium indicator that improves sensitivity and performance compared to existing green and red indicators for neural imaging.

This paper develops excitation ratiometric fluorescent protein biosensors for citrate, enabling quantitative analysis of citrate dynamics in different cellular compartments and populations.

The paper develops Siglec-liposomes to detect Siglec ligands and modulate immune cell function, showing they enhance T cell proliferation.

The paper develops high-performance green and red fluorescent biosensors for pyruvate with large fluorescence intensity changes and varying affinities, enabling multicolor imaging in mammalian cells.