Author

Mette Ahrensback Roesgaard

University of BaselORCID 0000-0002-7927-8704Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:protein folding & dynamics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Jan Pieter AbrahamsiD· 2 shared Niko SchenckiD· 2 shared Philipp Carlos Armbruster· 1 shared Timothy SharpeiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

4 top collaborators · 6 mutual co-author links

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2 shared papersBiochemistry

Jan Pieter AbrahamsORCID

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2 papers

Recent·Most cited

Mitochondrial Lon protease couples substrate translocation to proteolytic activation

Niko Schenck, Mette Ahrensback Roesgaard, Jan Pieter Abrahams

This paper investigates how LonP1 protease uses ATP hydrolysis to regulate substrate translocation and proteolytic activation, showing that proteolysis of folded proteins requires ATP-driven unfolding and translocation.

bioRxiv · Jun 23, 2026 · PreprintBiochemistry

LonP1 chaperone-like activity is ATPase independent and is mediated by its N-domain

Mette Ahrensback Roesgaard, Philipp Carlos Armbruster, Timothy Sharpe, Niko Schenck, Jan Pieter Abrahams

This paper shows LonP1 inhibits fibrillar aggregate growth without ATPase activity, localizing chaperone function to its N-domain hexamer.

bioRxiv · May 18, 2026 · PreprintBiochemistry